Open AccessSmooth Muscle Progenitor Cells Derived From Human Pluripotent Stem Cells Induce Histologic Changes in Injured Urethral Sphincter
Author(s) -
Li Yanhui,
Wen Yan,
Wang Zhe,
Wei Yi,
Wani Prachi,
Green Morgaine,
Swaminathan Ganesh,
Ramamurthi Anand,
Pera Renee Reijo,
Chen Bertha
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2016-0035
Subject(s) - progenitor cell , induced pluripotent stem cell , stem cell , human induced pluripotent stem cells , microbiology and biotechnology , anatomy , biology , pathology , medicine , embryonic stem cell , biochemistry , gene
In vivo integration of smooth muscle progenitor cells (pSMCs) derived from human pluripotent stem cells was examined. pSMCs were derived from a human embryonic stem cell line and two induced pluripotent stem cell lines. The data suggest that hPSC‐derived pSMCs facilitate restoration of urethral sphincter function by direct smooth muscle cell regeneration and by inducing native tissue elastin/collagen III remodeling.