Open AccessHuman Endomyocardial Biopsy Specimen‐Derived Stromal Cells Modulate Angiotensin II‐Induced Cardiac Remodeling
Author(s) -
Miteva Kapka,
Van Linthout Sophie,
Pappritz Kathleen,
Müller Irene,
Spillmann Frank,
Haag Marion,
Stachelscheid Harald,
Ringe Jochen,
Sittinger Michael,
Tschöpe Carsten
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2016-0031
Subject(s) - angiotensin ii , endocrinology , medicine , fibrosis , myofibroblast , ventricular remodeling , stromal cell , cardiac fibrosis , muscle hypertrophy , biology , heart failure , chemistry , receptor
This study evaluated whether intramyocardial injection of cardiac‐derived adherent proliferating cells (CardAPs) modulates cardiac fibrosis and hypertrophy in a mouse model of angiotensin II (Ang II)‐induced systolic heart failure and analyzed underlying mechanisms. Among other findings, results indicated that intramyocardial injection of CardAPs improved left ventricular (LV) function and reduced LV remodeling. These improvements were attributed to antifibrotic and antihypertrophic effects resulting from paracrine actions and immunomodulatory properties.