Open AccessAutophagy Improves the Immunosuppression of CD4 + T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor‐β1
Author(s) -
Gao Liangbin,
Cen Shuizhong,
Wang Peng,
Xie Zhongyu,
Liu Zhenhua,
Deng Wen,
Su Hongjun,
Wu Xiaohua,
Wang Shan,
Li Jinteng,
Ouyang Yi,
Wu Yanfeng,
Shen Huiyong
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0420
Subject(s) - autophagy , mesenchymal stem cell , immunosuppression , transforming growth factor , microbiology and biotechnology , cancer research , secretion , biology , immunology , apoptosis , endocrinology , biochemistry
Whether autophagy will affect the therapeutic efficacy of mesenchymal stem cells (MSCs) is largely unknown. It is demonstrated that autophagy could improve the immunosuppression of CD4 + T cells by MSCs through transforming growth factor‐β1. Therefore, regulation of autophagy in MSCs would provide a promising strategy to improve the therapeutic efficacy of these cells.