Open AccessConcise Review: In Vitro Formation of Bone ‐ Like Nodules Sheds Light on the Application of Stem Cells for Bone Regeneration
Author(s) -
Mechiche Alami Saad,
Gangloff Sophie C.,
Laurent-Maquin Dominique,
Wang Yun,
Kerdjoudj Halima
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0413
Subject(s) - stem cell , osteoblast , microbiology and biotechnology , regenerative medicine , mesenchymal stem cell , regeneration (biology) , biology , cellular differentiation , context (archaeology) , in vitro , genetics , paleontology , gene
This review summarize the studies deciphering the mechanisms that govern osteoblast differentiation in the context of in vitro formation of bone ‐ like nodules, including morphologic and molecular events as well as cellular contributions to mineral nucleation, occurring during osteogenic differentiation of stem cells. Also highlighted are the limitations of current translational applications of stem cells and opportunities to use the bone ‐ like nodule model for bone regenerative therapies.