Open AccessTreatment of Crohn's‐Related Rectovaginal Fistula With Allogeneic Expanded‐Adipose Derived Stem Cells: A Phase I–IIa Clinical Trial
Author(s) -
García-Arranz Mariano,
Herreros Maria Dolores,
González-Gómez Carolina,
de la Quintana Paloma,
Guadalajara Héctor,
Georgiev-Hristov Tihomir,
Trébol Jacobo,
Garcia-Olmo Damián
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0356
Subject(s) - stem cell , adipose tissue , rectovaginal fistula , medicine , clinical trial , crohn's disease , immunology , fistula , surgery , biology , disease , genetics
This clinical trial was to determine the safety and feasibility of expanded allogeneic adipose‐derived stem cells to treat Crohn’s‐related rectovaginal fistula (CRRVF). Sixty percent of the nonexcluded patients achieved a complete healing. This is a safe and feasible therapy for treating CRRVF, and the healing success rate appears promising.