Open AccessMicroRNA‐146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury
Author(s) -
Zhu Yuan,
Yu Jing,
Yin Lei,
Zhou Ying,
Sun Zixuan,
Jia Haoyuan,
Tao Yang,
Liu Wanzhu,
Zhang Bin,
Zhang Jiao,
Wang Mei,
Zhang Xu,
Yan Yongmin,
Xue Jianguo,
Gu Hongbin,
Mao Fei,
Xu Wenrong,
Qian Hui
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0355
Subject(s) - acute kidney injury , downregulation and upregulation , medicine , renal stem cell , microrna , creatinine , mesenchymal stem cell , kidney , cisplatin , cancer research , biomarker , stem cell , pathology , microbiology and biotechnology , biology , chemotherapy , biochemistry , progenitor cell , gene
Altered microRNAs in renal tissues from cisplatin‐induced acute kidney injury (AKI) rats treated with or without rat bone marrow mesenchymal stem cells were profiled. MicroRNA‐146b (miR‐146b) inhibition induced ErbB4 expression, resulting in enhanced proliferation of injured renal tubular epithelial cells. Elevated miR‐146b expression contributed to cisplatin‐induced AKI, partly through ErbB4 downregulation. MiR‐146b might be an early biomarker for AKI, and miR‐146b inhibition could be a novel strategy for AKI treatment.