Open AccessAllogeneic Mesenchymal Stem Cell Therapy Promotes Osteoblastogenesis and Prevents Glucocorticoid‐Induced Osteoporosis
Author(s) -
Sui Bingdong,
Hu Chenghu,
Zhang Xinyi,
Zhao Pan,
He Tao,
Zhou Cuihong,
Qiu Xinyu,
Chen Nan,
Zhao Xinyi,
Jin Yan
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0347
Subject(s) - homing (biology) , mesenchymal stem cell , bone marrow , osteoblast , cancer research , cell therapy , immunology , progenitor cell , medicine , stem cell , chemistry , microbiology and biotechnology , biology , pathology , ecology , biochemistry , in vitro
To study the potential of mesenchymal stem cells (MSCs) without genetic manipulation to treat osteoporosis, the authors transplanted MSCs into mice with glucocorticoid‐induced murine osteoporosis. MSCs prevented the reduction of bone mass and strength. Donor bone marrow MSCs homed and inhabited recipient bone marrow for at least 4 weeks, prevented recipient bone marrow cell apoptosis, and induced recipient osteoblastogenesis.