Open AccessAntifibrotic Activity of Human Placental Amnion Membrane‐Derived CD34 + Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide‐Induced Liver Injury
Author(s) -
Lee Po-Huang,
Tu Chi-Tang,
Hsiao Chih-Chiang,
Tsai Ming-Song,
Ho Cheng-Maw,
Cheng Nai-Chen,
Hung Tzu-Min,
Shih Daniel Tzu-bi
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0343
Subject(s) - mesenchymal stem cell , stem cell , cancer research , cd34 , progenitor cell , biology , transplantation , immunology , pathology , medicine , microbiology and biotechnology
This study aimed to evaluate the therapeutic effect of mesenchymal stromal cell (MSC)‐based cell transplantation as an alternative treatment for liver fibrosis. When injected into the spleen of thioacetamide‐injured mice, human placental amnion membrane‐derived MSCs can engraft into the injury site, ameliorate liver fibrosis, and restore liver function,