Open AccessEngineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure
Author(s) -
Braid Lorena R.,
Hu Wei-Gang,
Davies John E.,
Nagata Les P.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0341
Subject(s) - virology , antibody , immune system , immunity , neutralizing antibody , venezuelan equine encephalitis virus , immunology , mesenchymal stem cell , biology , virus , medicine , encephalitis , microbiology and biotechnology
Engineered mesenchymal stromal cells provide a useful, effective platform for protection against infectious disease. Venezuelan equine encephalitis virus (VEEV) is a mosquito‐borne pathogen affecting humans and equines that can be used in bio‐warfare, with no licensed vaccine or antiviral agent available to combat VEEV infection in humans. Human umbilical cord perivascular cell‐mediated antibody gene therapy is a novel technology for immediate and sustained passive immunity against a significant bio‐warfare threat.