Open AccessEffect of Function‐Enhanced Mesenchymal Stem Cells Infected With Decorin‐Expressing Adenovirus on Hepatic Fibrosis
Author(s) -
Jang Yoon Ok,
Cho Mee-Yon,
Yun Chae-Ok,
Baik Soon Koo,
Park Kyu-Sang,
Cha Seung-Kuy,
Chang Sei Jin,
Kim Moon Young,
Lim Yoo Li,
Kwon Sang Ok
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0323
Subject(s) - decorin , mesenchymal stem cell , hepatic stellate cell , hepatic fibrosis , fibrosis , cancer research , cirrhosis , extracellular matrix , biology , chemistry , microbiology and biotechnology , medicine , pathology , endocrinology , proteoglycan
A combination treatment consisting of bone marrow‐derived mesenchymal stem cells (BM‐MSCs) and decorin strongly inhibited the progression of thioacetamide‐induced hepatic fibrosis in rats, compared with BM‐MSCs alone. Treatment with BM‐MSCs infected with decorin‐expressing adenovirus could constitute a novel and efficient therapeutic approach for patients with intractable cirrhosis.