Open AccessOpposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth
Author(s) -
Zheng Huilin,
Zou Weibin,
Shen Jiaying,
Xu Liang,
Wang Shu,
Fu Yang-Xin,
Fan Weimin
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0300
Subject(s) - mesenchymal stem cell , cancer research , bone marrow , tumor microenvironment , stromal cell , immunology , biology , proinflammatory cytokine , metastasis , immune system , medicine , cancer , pathology , inflammation , genetics
Although mesenchymal stem cells (MSCs) usually promote tumor growth and metastasis, in a breast tumor 4T1 cell‐based animal model, this study determined that coinjection and distant injection of allogeneic bone marrow‐derived MSCs with tumor cells promoted or suppressed tumor growth in different ways. Distant injection of MSCs also decreased the accumulation of myeloid‐derived suppressor cells and regulatory T cells in tumor tissues by enhancing proinflammatory factors.