Open AccessDevelopment of a Functional Biomarker for Use in Cell‐Based Therapy Studies in Seropositive Rheumatoid Arthritis
Author(s) -
Shalev-Malul Gali,
Soler David C.,
Ting Anthony E.,
Lehman Nicholas A.,
Barnboym Emma,
McCormick Thomas S.,
Anthony Donald D.,
Lazarus Hillard M.,
Caplan Arnold I.,
Breitman Maya,
Singer Nora G.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0299
Subject(s) - cell therapy , mesenchymal stem cell , medicine , immune system , progenitor cell , rheumatoid arthritis , ex vivo , immunology , biomarker , arthritis , stem cell , in vivo , biology , pathology , microbiology and biotechnology , biochemistry
This study tested the hypothesis that an ex vivo T‐cell suppression assay could estimate response to novel cell‐based therapy for rheumatoid arthritis (RA). Results showed multipotent adult progenitor cell products suppressed RA effector T cells. The study demonstrated the feasibility of using suppressor assays to detect biological effects of cell‐based therapy in RA and suggests these effects are dose‐dependent.