Human Umbilical Cord‐Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia | Zendy

Liu Chuan-Bin | Zendy; Huang He | Zendy; Sun Ping | Zendy; Ma Shi-Ze | Zendy; Liu An-Heng | Zendy; Xue Jian | Zendy; Fu Jin-Hui | Zendy; Liang Yu-Qian | Zendy; Liu Bing | Zendy; Wu Dong-Ying | Zendy; Lü Shuang-Hong | Zendy; Zhang Xiao-Zhong | Zendy

Open Access

Human Umbilical Cord‐Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia

Author(s) -

Liu Chuan-Bin,

Huang He,

Sun Ping,

Ma Shi-Ze,

Liu An-Heng,

Xue Jian,

Fu Jin-Hui,

Liang Yu-Qian,

Liu Bing,

Wu Dong-Ying,

Lü Shuang-Hong,

Zhang Xiao-Zhong

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0298

Subject(s) - medicine , ejection fraction , mesenchymal stem cell , cardiology , umbilical cord , transplantation , perfusion , ischemia , myocardial infarction , ventricular remodeling , cardiac function curve , heart failure , pathology , anatomy

Many patients with chronic myocardial ischemia are not suitable for surgery and have no effective drug treatment. This study finds that umbilical cord‐derived mesenchymal stromal cells transplanted by intracoronary delivery combined with two intravenous administrations was safe and could significantly improve left ventricular function, perfusion, and remodeling in a large‐animal model of chronic myocardial ischemia.

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