Open AccessHuman Umbilical Cord‐Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia
Author(s) -
Liu Chuan-Bin,
Huang He,
Sun Ping,
Ma Shi-Ze,
Liu An-Heng,
Xue Jian,
Fu Jin-Hui,
Liang Yu-Qian,
Liu Bing,
Wu Dong-Ying,
Lü Shuang-Hong,
Zhang Xiao-Zhong
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0298
Subject(s) - medicine , ejection fraction , cardiology , mesenchymal stem cell , umbilical cord , perfusion , transplantation , ventricular remodeling , ischemia , myocardial infarction , cardiac function curve , coronary artery disease , heart failure , pathology , anatomy
Many patients with chronic myocardial ischemia are not suitable for surgery and have no effective drug treatment. This study finds that umbilical cord‐derived mesenchymal stromal cells transplanted by intracoronary delivery combined with two intravenous administrations was safe and could significantly improve left ventricular function, perfusion, and remodeling in a large‐animal model of chronic myocardial ischemia.