Open Access
Strategies and Challenges to Myocardial Replacement Therapy
Author(s) -
Feric Nicole T.,
Radisic Milica
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0288
Subject(s) - regenerative medicine , cell therapy , myocardial infarction , medicine , transplantation , ventricle , regeneration (biology) , stem cell therapy , heart failure , intensive care medicine , heart transplantation , heart disease , neuroscience , stem cell , cardiology , psychology , biology , microbiology and biotechnology , genetics
Cardiac cell‐based regenerative therapies include application of a cell suspension and the implantation of an in vitro engineered tissue construct to the damaged area of the heart. Both strategies have their advantages and challenges. This review discusses the current state of the art in myocardial regeneration, the challenges to success, and the future direction of the field.