Open AccessMesenchymal Stem Cell‐Derived Exosomes Promote Fracture Healing in a Mouse Model
Author(s) -
Furuta Taisuke,
Miyaki Shigeru,
Ishitobi Hiroyuki,
Ogura Toshihiko,
Kato Yoshio,
Kamei Naosuke,
Miyado Kenji,
Higashi Yukihito,
Ochi Mitsuo
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0285
Subject(s) - microvesicles , paracrine signalling , mesenchymal stem cell , microbiology and biotechnology , exosome , bone healing , stem cell , regeneration (biology) , stromal cell , biology , cancer research , microrna , anatomy , biochemistry , receptor , gene
This study evaluated the role of exosomes isolated from mesenchymal stem cell (MSC)‐conditioned medium (CM) in the fracture‐healing process of CD9 −/− mice, which produce reduced levels of exosomes. Retardation of fracture healing in CD9 −/− mice was rescued by the injection of MSC exosomes, but not exosome‐free CM, showing that MSC exosomes are a novel factor of MSC paracrine signaling, with an important role in the tissue repair process.