Open AccessEmbryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation
Author(s) -
Bargehr Johannes,
Low Lucinda,
Cheung Christine,
Bernard William G.,
Iyer Dharini,
Bennett Martin R.,
Gambardella Laure,
Sinha Sanjay
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0282
Subject(s) - midkine , biology , matrigel , microbiology and biotechnology , embryonic stem cell , angiogenesis , mural cell , paracrine signalling , endothelial stem cell , immunology , in vitro , cancer research , genetics , gene , growth factor , receptor
Smooth muscle cells (SMCs) from distinct embryonic origins differ in their ability to support human umbilical vein endothelial cell (HUVEC) network formation. Lateral mesoderm‐derived SMCs best supported endothelial cell network complexity and survival in vitro, in part through increased expression of midkine. A lineage‐specific approach might be beneficial for vascular tissue engineering and therapeutic revascularization.