Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation | Zendy

Bargehr Johannes | Zendy; Low Lucinda | Zendy; Cheung Christine | Zendy; Bernard William G. | Zendy; Iyer Dharini | Zendy; Bennett Martin R. | Zendy; Gambardella Laure | Zendy; Sinha Sanjay | Zendy

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Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation

Author(s) -

Bargehr Johannes,

Low Lucinda,

Cheung Christine,

Bernard William G.,

Iyer Dharini,

Bennett Martin R.,

Gambardella Laure,

Sinha Sanjay

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0282

Subject(s) - microbiology and biotechnology , smooth muscle , biology , myocyte , computational biology , endocrinology

Smooth muscle cells (SMCs) from distinct embryonic origins differ in their ability to support human umbilical vein endothelial cell (HUVEC) network formation. Lateral mesoderm‐derived SMCs best supported endothelial cell network complexity and survival in vitro, in part through increased expression of midkine. A lineage‐specific approach might be beneficial for vascular tissue engineering and therapeutic revascularization.

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