Open AccessApoptosis‐Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction
Author(s) -
Aonuma Tatsuya,
Takehara Naofumi,
Maruyama Keisuke,
Kabara Maki,
Matsuki Motoki,
Yamauchi Atsushi,
Kawabe Jun-ichi,
Hasebe Naoyuki
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0281
Subject(s) - dna (apurinic or apyrimidinic site) lyase , apoptosis , cancer research , myocyte , biology , microbiology and biotechnology , ap site , endonuclease , gene , biochemistry
To determine whether apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) overexpression in cardiac progenitor cells (CPCs) could ameliorate the efficiency of cell‐based therapy, oxidative stress‐induced apoptosis was assessed. The antiapoptotic APE1‐CPC graft increased TAK1‐NF‐κB pathway activation, survived effectively in the ischemic heart, restored cardiac function, and reduced cardiac inflammation and fibrosis.