Open AccessMechanical Stretching Promotes Skin Tissue Regeneration via Enhancing Mesenchymal Stem Cell Homing and Transdifferentiation
Author(s) -
Liang Xiao,
Huang Xiaolu,
Zhou Yiwen,
Jin Rui,
Li Qingfeng
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0274
Subject(s) - mesenchymal stem cell , homing (biology) , transdifferentiation , microbiology and biotechnology , biology , wnt signaling pathway , stem cell , downregulation and upregulation , cancer research , signal transduction , ecology , biochemistry , gene
To clarify the underlying mechanisms of how mesenchymal stem cells (MSCs) promote skin expansion and help ameliorate complications, the authors identified the differentially expressed genes between mechanically stretched human MSCs and controls. Microarray analysis suggested upregulation of genes related to hypoxia, vascularization, and cell proliferation, enhancing transplanted MSC homing to the expanded skin and transdifferentiation into epidermal basal cells and endothelial cells.