Open AccessType 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro
Author(s) -
Davies Lindsay C.,
Alm Jessica J.,
Heldring Nina,
Moll Guido,
Gavin Caroline,
Batsis Ioannis,
Qian Hong,
Sigvardsson Mikael,
Nilsson Bo,
Kyllonen Lauri E.,
Salmela Kaija T.,
Carlsson Per-Ola,
Korsgren Olle,
Le Blanc Katarina
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0272
Subject(s) - mesenchymal stem cell , immunology , cell therapy , medicine , peripheral blood mononuclear cell , stromal cell , immune system , bone marrow , immunotherapy , in vitro , cancer research , biology , stem cell , pathology , microbiology and biotechnology , biochemistry
The authors used gene array in combination with functional in vitro assays to study mesenchymal stromal cells (MSCs) from donors with type 1 diabetes (T1D) and healthy controls. Gene expression (cytokine secretion, immunomodulatory activity, and wound healing potential) differed between the groups. Cell count, growth kinetics, and colony‐forming unit‐fibroblast capacity were comparable, and MSCs from the two groups were similar in immunosuppressive activity, migratory capacity, and hemocompatibility.