Open AccessGrafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus
Author(s) -
Shetty Ashok K.,
Hattiangady Bharathi
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0270
Subject(s) - subventricular zone , neun , neural stem cell , subgranular zone , doublecortin , biology , neurogenesis , stem cell , progenitor cell , microbiology and biotechnology , olig2 , rostral migratory stream , immunology , hippocampus , neuroscience , oligodendrocyte , dentate gyrus , central nervous system , immunohistochemistry , myelin
The engraftment and differentiation of alkaline phosphatase‐positive neural stem cells (NSCs) expanded from the postnatal subventricular zone (SVZ), 3 months after grafting into the intact young or aged rat hippocampus, were examined. Both young and aged hippocampi supported robust engraftment and similar differentiation of SVZ‐NSC graft‐derived cells.