Open AccessExpansion and Hepatic Differentiation of Adult Blood‐Derived CD34 + Progenitor Cells and Promotion of Liver Regeneration After Acute Injury
Author(s) -
Hu Min,
Li Shaowei,
Me Siddharth,
Liu Bo,
Hu Michael S.,
Longaker Michael T.,
Lorenz H. Peter
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0268
Subject(s) - progenitor cell , liver regeneration , stem cell , cd34 , regeneration (biology) , biology , hepatocyte , liver injury , regenerative medicine , cell therapy , haematopoiesis , immunology , cancer research , cellular differentiation , liver disease , microbiology and biotechnology , pharmacology , in vitro , biochemistry , gene
A new group of blood‐derived CD34 + progenitor cells (BDPCs) with the ability to expand and differentiate into functional hepatocyte‐like cells and promote liver regeneration is reported. With their ease of access, application through the peripheral blood, and the capability of rapid expansion and hepatic differentiation, BDPCs have great potential as a cell‐based therapy for liver disease.