WNT‐C59, a Small‐Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells | Zendy

Motono Makoto | Zendy; Ioroi Yoshihiko | Zendy; Ogura Takenori | Zendy; Takahashi Jun | Zendy

Open Access

WNT‐C59, a Small‐Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells

Author(s) -

Motono Makoto,

Ioroi Yoshihiko,

Ogura Takenori,

Takahashi Jun

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0261

Subject(s) - wnt signaling pathway , induced pluripotent stem cell , neuroscience , microbiology and biotechnology , cortex (anatomy) , motor cortex , biology , human induced pluripotent stem cells , stem cell , chemistry , gene , embryonic stem cell , biochemistry , signal transduction , stimulation

This article reports a novel differentiation method using a small‐molecule WNT inhibitor, WNT‐C59 (C59), to efficiently induce human anterior cortex. C59 efficiently induced CTIP2 + /COUP‐TF1 − cells, which are characteristic of the cells found in the anterior cortex. These results raise the possibility of C59 contributing to cell replacement therapy for motor neuron diseases or insults.

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