Open AccessWNT‐C59, a Small‐Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells
Author(s) -
Motono Makoto,
Ioroi Yoshihiko,
Ogura Takenori,
Takahashi Jun
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0261
Subject(s) - wnt signaling pathway , induced pluripotent stem cell , dkk1 , biology , neuroscience , microbiology and biotechnology , neurogenesis , neural stem cell , stem cell , embryonic stem cell , signal transduction , biochemistry , gene
This article reports a novel differentiation method using a small‐molecule WNT inhibitor, WNT‐C59 (C59), to efficiently induce human anterior cortex. C59 efficiently induced CTIP2 + /COUP‐TF1 − cells, which are characteristic of the cells found in the anterior cortex. These results raise the possibility of C59 contributing to cell replacement therapy for motor neuron diseases or insults.