Open AccessConcise Review: Updated Advances and Current Challenges in Cell Therapy for Inborn Liver Metabolic Defects
Author(s) -
Najimi Mustapha,
Defresne Florence,
Sokal Etienne M.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0260
Subject(s) - transplantation , liver transplantation , clinical trial , intensive care medicine , medicine , immunosuppression , liver disease , economic shortage , population , disease , cell therapy , bioinformatics , biology , cell , immunology , surgery , pathology , linguistics , philosophy , genetics , environmental health , government (linguistics)
This review updates the status of liver cell transplantation (LCT). Advances in LCT require standardization of biological material and immunosuppression regimens, as well as optimizing the most efficient cell population to be transplanted. Isolated hepatocytes show positive clinical results but have poor resistance to both cryopreservation and in vitro culture. More standardized and widely accessible cell medicinal products are aimed at improving engraftment permanency and post‐cell transplantation metabolic effects.