Open AccessGenetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell‐Like Cells
Author(s) -
Tang Zi-Hua,
Chen Jia-Rong,
Zheng Jing,
Shi Hao-Song,
Ding Jie,
Qian Xiao-Dan,
Zhang Cui,
Chen Jian-Ling,
Wang Cui-Cui,
Li Liang,
Chen Jun-Zhen,
Yin Shan-Kai,
Huang Tao-Sheng,
Chen Ping,
Guan Min-Xin,
Wang Jin-Fu
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0252
Subject(s) - induced pluripotent stem cell , biology , stem cell , mutation , genetics , microbiology and biotechnology , embryonic stem cell , gene
The genetic correction of induced pluripotent stem cells (iPSCs) from somatic cells of patients with hereditary sensorineural hearing loss is a promising treatment method. Hair cell‐like cells induced from corrected iPSCs showed restored organization of stereocilia‐like protrusions. The electrophysiological function of these cells was similar to that of cells induced from other iPSCs. These results might facilitate the development of iPSC‐based gene therapy for genetic disorders.