Open AccessEnhanced Osteogenesis of Adipose‐Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists
Author(s) -
Fan Jiabing,
Im Choong Sung,
Guo Mian,
Cui Zhong-Kai,
Fartash Armita,
Kim Soyon,
Patel Nikhil,
Bezouglaia Olga,
Wu Benjamin M.,
Wang Cun-Yu,
Aghaloo Tara L.,
Lee Min
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0249
Subject(s) - noggin , bone morphogenetic protein , stem cell , microbiology and biotechnology , bone healing , chemistry , adipose tissue , bone morphogenetic protein 2 , medicine , biology , anatomy , biochemistry , in vitro , gene
The direct use of adipose‐derived stem cells (ASCs) alone has had limited success in the treatment of large bone defects. This study used an alternative approach that complements bone morphogenetic protein (BMP) activity to maximize the osteogenesis of ASCs by regulating levels of antagonists and agonists to BMP signaling. Findings indicate promising stem cell‐based therapy for treating bone defects that can effectively complement or replace current osteoinductive therapeutics.