Open AccessTargeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium
Author(s) -
Choudhary Parul,
Gutteridge Alex,
Impey Emma,
Storer R. Ian,
Owen Robert M.,
Whiting Paul J.,
Bictash Magda,
Benn Caroline L.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0247
Subject(s) - microbiology and biotechnology , retinal pigment epithelium , stem cell , embryonic stem cell , macular degeneration , biology , cell growth , cell , retinal , transplantation , cancer research , medicine , biochemistry , ophthalmology , gene
Stem cell derived retinal pigment epithelium (RPE) holds promise as a cell replacement therapy for macular degeneration. This work demonstrates the role of the cAMP and transforming growth factor β signaling pathways in RPE epithelialization in vitro. Modulation of these pathways by small molecules leads to increased efficiency of RPE generation with a higher yield.