Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium | Zendy

Choudhary Parul | Zendy; Gutteridge Alex | Zendy; Impey Emma | Zendy; Storer R. Ian | Zendy; Owen Robert M. | Zendy; Whiting Paul J. | Zendy; Bictash Magda | Zendy; Benn Caroline L. | Zendy

Open Access

Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium

Author(s) -

Choudhary Parul,

Gutteridge Alex,

Impey Emma,

Storer R. Ian,

Owen Robert M.,

Whiting Paul J.,

Bictash Magda,

Benn Caroline L.

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0247

Subject(s) - microbiology and biotechnology , retinal pigment epithelium , stem cell , embryonic stem cell , macular degeneration , biology , cell growth , cell , retinal , transplantation , cancer research , medicine , biochemistry , ophthalmology , gene

Stem cell derived retinal pigment epithelium (RPE) holds promise as a cell replacement therapy for macular degeneration. This work demonstrates the role of the cAMP and transforming growth factor β signaling pathways in RPE epithelialization in vitro. Modulation of these pathways by small molecules leads to increased efficiency of RPE generation with a higher yield.

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