Open AccessAge‐Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure
Author(s) -
Agarwal Udit,
Smith Amanda W.,
French Kristin M.,
Boopathy Archana V.,
George Alex,
Trac David,
Brown Milton E.,
Shen Ming,
Jiang Rong,
Fernandez Janet D.,
Kogon Brian E.,
Kanter Kirk R.,
Alsoufi Baahaldin,
Wagner Mary B.,
Platt Manu O.,
Davis Michael E.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0241
Subject(s) - medicine , heart failure , ejection fraction , ventricle , cardiology , progenitor cell , stem cell , biology , genetics
To investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling, the authors injected neonate, infant, or child hCPCs into rats with right ventricular heart failure. Mechanisms including migration and proliferation assays, as suggested by computational modeling, showed improved chemotactic and proliferative capacity of neonatal hCPCs compared with infant or child hCPCs. Thus, the reparative potential of hCPCs is age‐dependent.