Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix—A Comparative Analysis of Bioartificial Liver Microenvironments | Zendy

Wang Bo | Zendy; Jakus Adam E. | Zendy; Baptista Pedro M. | Zendy; Soker Shay | Zendy; Soto-Gutierrez Alejandro | Zendy; Abecassis Michael M. | Zendy; Shah Ramille N. | Zendy; Wertheim Jason A. | Zendy

Open Access

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix—A Comparative Analysis of Bioartificial Liver Microenvironments

Author(s) -

Wang Bo,

Jakus Adam E.,

Baptista Pedro M.,

Soker Shay,

Soto-Gutierrez Alejandro,

Abecassis Michael M.,

Shah Ramille N.,

Wertheim Jason A.

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0235

Subject(s) - induced pluripotent stem cell , extracellular matrix , microbiology and biotechnology , chemistry , bioartificial liver device , scaffold , stem cell , hepatocyte , decellularization , embryonic stem cell , tissue engineering , biology , biochemistry , in vitro , biomedical engineering , medicine , gene , genetics

The ability of two three‐dimensional bioscaffold systems to reverse the primary limitations of induced pluripotent stem cell (iPSC)‐derived hepatocytes was compared. Proliferation and function of iPSC hepatocytes were significantly enhanced when cultured within scaffolds made from extracellular matrix (ECM). This ECM scaffold enhanced phenotypic maturation of iPSC hepatocytes compared with other platforms, likely owing to its biologically diverse makeup.

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