Open AccessLinking Pluripotency Reprogramming and Cancer
Author(s) -
Iglesias Juan Manuel,
Gumuzio Juan,
Martin Angel G.
Publication year - 2017
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0225
Subject(s) - reprogramming , sox2 , induced pluripotent stem cell , biology , stem cell , cancer stem cell , computational biology , microbiology and biotechnology , cancer research , cell , embryonic stem cell , genetics , gene
Summary Tumor development and the generation of induced pluripotent stem cells are highly comparable processes with striking similarities. Cellular plasticity is inherent to tumor evolution, rendering cells that acquire a stem cell‐like phenotype, for which Sox2 activation has proved instrumental for the plastic acquisition of stemness properties in tumor cells. Understanding the molecular mechanisms underlying both events might uncover novel approaches for the development of anticancer therapeutics and constitute model systems for understanding tumor generation and ensuring the biosafety of cell‐based therapies. S tem C ells T ranslational M edicine 2017;6:335–339