Open AccessPreischemic Administration of Nonexpanded Adipose Stromal Vascular Fraction Attenuates Acute Renal Ischemia/Reperfusion Injury and Fibrosis
Author(s) -
Zhou Liuhua,
Xu Luwei,
Shen Jiangwei,
Song Qun,
Wu Ran,
Ge Yuzheng,
Xin Hui,
Zhu Jiageng,
Wu Jianping,
Jia Ruipeng
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0223
Subject(s) - stromal vascular fraction , medicine , acute kidney injury , kidney , adipose tissue , transplantation , renal ischemia , kidney disease , progenitor cell , ischemia , fibrosis , stromal cell , mesenchymal stem cell , reperfusion injury , stem cell , pathology , biology , genetics
This study demonstrates that preischemic administration of uncultured stromal vascular fraction could increase cell retention and then improve renal function and structure at both early and long‐term stage after renal ischemia/reperfusion (IR), which may provide a novel therapeutic approach for IR injury.