Open AccessMesenchymal Stromal Cell‐Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia‐Ischemia
Author(s) -
Ophelders Daan R.M.G.,
Wolfs Tim G.A.M.,
Jellema Reint K.,
Zwanenburg Alex,
Andriessen Peter,
Delhaas Tammo,
Ludwig Anna-Kristin,
Radtke Stefan,
Peters Vera,
Janssen Leon,
Giebel Bernd,
Kramer Boris W.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0197
Subject(s) - mesenchymal stem cell , medicine , neuroprotection , ischemia , brain damage , hypoxia (environmental) , systemic administration , inflammation , pharmacology , pathology , immunology , biology , in vivo , chemistry , microbiology and biotechnology , organic chemistry , oxygen
The protective effects of mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) were studied in an ovine preclinical model of preterm hypoxic‐ischemic brain injury. Systemic in utero administration of MSC‐EVs improved brain function by reducing the total number and duration of seizures and by preserving baroreceptor reflex sensitivity. These functional protections were accompanied by a tendency to prevent hypomyelination. Cerebral inflammation remained unaffected by the MSC‐EV treatment.