Open AccessEffects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease
Author(s) -
Rodriguez-Pallares Jannette,
Rodriguez-Perez Ana I.,
Muñoz Ana,
Parga Juan A.,
Toledo-Aral Juan J.,
Labandeira-Garcia Jose L.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0182
Subject(s) - dopaminergic , neuroprotection , programmed cell death , dopamine , parkinson's disease , pharmacology , chemistry , apoptosis , medicine , biology , neuroscience , disease , biochemistry
The present results discourage the treatment of suspensions of dopaminergic precursors with Rho kinase (ROCK) inhibitors in the pregrafting period. However, treatment of the host induces a marked increase in graft‐derived striatal reinnervation. Because ROCK inhibitors have also exerted neuroprotective effects in several models of Parkinson's disease, treatment of the host with ROCK inhibitors, currently used against vascular diseases in clinical practice, before and after grafting may be a useful adjuvant to cell therapy in Parkinson's.