Open AccessAdipose‐Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA‐31
Author(s) -
Kang Ting,
Jones Tia M.,
Naddell Clayton,
Bacanamwo Methode,
Calvert John W.,
Thompson Winston E.,
Bond Vincent C.,
Chen Y. Eugene,
Liu Dong
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0177
Subject(s) - angiogenesis , microvesicles , microbiology and biotechnology , matrigel , microvesicle , stem cell , endothelial stem cell , microrna , chemistry , adipose tissue , biology , immunology , cancer research , in vitro , biochemistry , gene
The potential effects of stem cell‐released microvesicles (MVs) in proangiogenic therapy were explored. MVs were released from adipose‐derived stem cells (ASCs) and were able to increase the migration and tube formation of human umbilical vein endothelial cells. MVs from ASCs, particularly from endothelial differentiation medium‐preconditioned ASCs, were found to have elevated levels of microRNA‐31 and to promote angiogenesis.