Open AccessEpicardium‐Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking
Author(s) -
Ding Zhaoping,
Temme Sebastian,
Quast Christine,
Friebe Daniela,
Jacoby Christoph,
Zanger Klaus,
Bidmon Hans-Jürgen,
Grapentin Christoph,
Schubert Rolf,
Flögel Ulrich,
Schrader Jürgen
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0159
Subject(s) - in vivo , chemistry , mesenchymal stem cell , microbiology and biotechnology , vasculogenesis , dapi , flow cytometry , progenitor cell , pathology , stem cell , biology , apoptosis , biochemistry , medicine
Epicardium‐derived cells (EPDCs) formed after myocardial infarction can specifically endocytose nanoparticles in vivo and in vitro. This novel feature permitted in vivo targeting of EPDCs with either a perfluorocarbon‐containing or rhodamine‐conjugated nanoemulsion to track migration and fate decision of EPDC with 19 F‐magnetic resonance imaging and fluorescence microscopy.