Open AccessLocal Application of Isogenic Adipose‐Derived Stem Cells Restores Bone Healing Capacity in a Type 2 Diabetes Model
Author(s) -
Wallner Christoph,
Abraham Stephanie,
Wagner Johannes Maximilian,
Harati Kamran,
Ismer Britta,
Kessler Lukas,
Zöllner Hannah,
Lehnhardt Marcus,
Behr Björn
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0158
Subject(s) - stem cell , adipose tissue , angiogenesis , regeneration (biology) , bone healing , mesenchymal stem cell , bone remodeling , neovascularization , endocrinology , microbiology and biotechnology , medicine , pathology , biology , anatomy
Stem cells obtained from fat pads of type 2 diabetic mice are found to be capable of reconstituting impaired bone regeneration in type 2 diabetes. These multipotent stem cells promote both angiogenesis and osteogenesis in type 2 diabetic bony defects.