Open AccessImpaired Angiogenic Potential of Human Placental Mesenchymal Stromal Cells in Intrauterine Growth Restriction
Author(s) -
Mandò Chiara,
Razini Paola,
Novielli Chiara,
Anelli Gaia Maria,
Belicchi Marzia,
Erratico Silvia,
Banfi Stefania,
Meregalli Mirella,
Tavelli Alessandro,
Baccarin Marco,
Rolfo Alessandro,
Motta Silvia,
Torrente Yvan,
Cetin Irene
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0155
Subject(s) - mesenchymal stem cell , biology , andrology , intrauterine growth restriction , stromal cell , population , adipogenesis , microbiology and biotechnology , stem cell , endocrinology , medicine , immunology , cancer research , genetics , fetus , pregnancy , environmental health
Features specific to intrauterine growth restriction (IUGR) may indicate a role of placental mesenchymal stromal cells in determining the specific placental phenotype associated with IUGR pathogenesis. Loss of endothelial differentiation potential and increase of adipogenic ability are likely to contribute to the vicious cycle of abnormal placental development in IUGR.