CD11b+ and Sca‐1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow‐Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation | Zendy

Cruz Fernanda F. | Zendy; Borg Zachary D. | Zendy; Goodwin Meagan | Zendy; Coffey Amy L. | Zendy; Wagner Darcy E. | Zendy; Rocco Patricia R.M. | Zendy; Weiss Daniel J. | Zendy

Open Access

CD11b+ and Sca‐1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow‐Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation

Author(s) -

Cruz Fernanda F.,

Borg Zachary D.,

Goodwin Meagan,

Coffey Amy L.,

Wagner Darcy E.,

Rocco Patricia R.M.,

Weiss Daniel J.

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0141

Subject(s) - peripheral blood mononuclear cell , bone marrow , inflammation , immunology , medicine , integrin alpha m , allergic inflammation , interleukin 17 , flow cytometry , biology , biochemistry , in vitro

A murine model of severe clinical asthma was used to study which bone marrow‐derived mononuclear cells (BMDMCs) are responsible for ameliorating airway hyperresponsiveness and lung inflammation. BMDMCs depleted of either CD11b‐positive cells (monocytes, macrophages, dendritic cells) or Sca‐1‐positive cells (bone marrow‐derived mesenchymal stromal cells) were unable to ameliorate these conditions in this model. Depletion of the other cell types did not diminish the ameliorating effects of BMDMC administration.

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