Open AccessCD11b+ and Sca‐1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow‐Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation
Author(s) -
Cruz Fernanda F.,
Borg Zachary D.,
Goodwin Meagan,
Coffey Amy L.,
Wagner Darcy E.,
Rocco Patricia R.M.,
Weiss Daniel J.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0141
Subject(s) - bone marrow , immunology , medicine , mesenchymal stem cell , inflammation , population , allergic inflammation , eosinophil , pathology , asthma , environmental health
A murine model of severe clinical asthma was used to study which bone marrow‐derived mononuclear cells (BMDMCs) are responsible for ameliorating airway hyperresponsiveness and lung inflammation. BMDMCs depleted of either CD11b‐positive cells (monocytes, macrophages, dendritic cells) or Sca‐1‐positive cells (bone marrow‐derived mesenchymal stromal cells) were unable to ameliorate these conditions in this model. Depletion of the other cell types did not diminish the ameliorating effects of BMDMC administration.