Open AccessVascular Smooth Muscle Cells From Hypertensive Patient‐Derived Induced Pluripotent Stem Cells to Advance Hypertension Pharmacogenomics
Author(s) -
Biel Nikolett M.,
Santostefano Katherine E.,
DiVita Bayli B.,
El Rouby Nihal,
Carrasquilla Santiago D.,
Simmons Chelsey,
Nakanishi Mahito,
Cooper-DeHoff Rhonda M.,
Johnson Julie A.,
Terada Naohiro
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0126
Subject(s) - induced pluripotent stem cell , pharmacogenomics , medicine , bioinformatics , drug discovery , single nucleotide polymorphism , vascular smooth muscle , biology , pharmacology , genetics , embryonic stem cell , smooth muscle , genotype , gene
Induced pluripotent stem cell (iPSC) technology provides a great interface to bring the cells of hyptertensive patients with their genomic data into the laboratory and to study hypertensive responses. As an initial step, the present study established an iPSC bank from patients with primary hypertension and demonstrated an effective and reproducible method of generating functional vascular smooth muscle cells.