Open AccessReducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs
Author(s) -
Szkolnicka Dagmara,
Lucendo-Villarin Baltasar,
Moore Joanna K.,
Simpson Kenneth J.,
Forbes Stuart J.,
Hay David C.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0117
Subject(s) - hepatocyte , microrna , acetaminophen , liver injury , liver cell , biology , toxicity , cell type , drug , cell , pharmacology , bioinformatics , medicine , in vitro , gene , genetics
With an aim of identifying interventions that could reduce or attenuate drug‐induced hepatocyte toxicity, hepatocytes were generated from a renewable resource and exposed to varying levels of paracetamol. A novel RNA that reduced paracetamol‐induced hepatocyte toxicity was identified, representing an important advance for the field.