Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications | Zendy

Poser Steven W. | Zendy; Chenoweth Josh G. | Zendy; Colantuoni Carlo | Zendy; Masjkur Jimmy | Zendy; Chrousos George | Zendy; Bornstein Stefan R. | Zendy; McKay Ronald D. | Zendy; Androutsellis-Theotokis Andreas | Zendy

Open Access

Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications

Author(s) -

Poser Steven W.,

Chenoweth Josh G.,

Colantuoni Carlo,

Masjkur Jimmy,

Chrousos George,

Bornstein Stefan R.,

McKay Ronald D.,

Androutsellis-Theotokis Andreas

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0105

Subject(s) - reprogramming , biology , stem cell , neural stem cell , signal transduction , microbiology and biotechnology , neuroscience , cell , computational biology , genetics

This study examined the appropriateness of common culture systems and their ability to reveal unusual (noncanonical) signal transduction pathways that actually operate in vivo. Novel pathways and their importance in various plastic cell types, culminating in their emerging roles in reprogramming mechanisms, and a number of reprogramming paradigms are also discussed. A new molecular perspective in the field of reprogramming with broad implications in basic, biotechnological, and translational research is introduced.

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