Open AccessConcise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications
Author(s) -
Poser Steven W.,
Chenoweth Josh G.,
Colantuoni Carlo,
Masjkur Jimmy,
Chrousos George,
Bornstein Stefan R.,
McKay Ronald D.,
Androutsellis-Theotokis Andreas
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0105
Subject(s) - reprogramming , biology , signal transduction , microbiology and biotechnology , transcription factor , phosphorylation , cell , genetics , gene
This study examined the appropriateness of common culture systems and their ability to reveal unusual (noncanonical) signal transduction pathways that actually operate in vivo. Novel pathways and their importance in various plastic cell types, culminating in their emerging roles in reprogramming mechanisms, and a number of reprogramming paradigms are also discussed. A new molecular perspective in the field of reprogramming with broad implications in basic, biotechnological, and translational research is introduced.