Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three‐Dimensional Rotary Culture System | Zendy

Yang Yiqing | Zendy; Liu CuiCui | Zendy; Lei Xiaohua | Zendy; Wang Hongtao | Zendy; Su Pei | Zendy; Ru Yongxin | Zendy; Ruan Xinhua | Zendy; Duan Enkui | Zendy; Feng Sizhou | Zendy; Han Mingzhe | Zendy; Xu Yuanfu | Zendy; Shi Lihong | Zendy; Jiang Erlie | Zendy; Zhou Jiaxi | Zendy

Open Access

Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three‐Dimensional Rotary Culture System

Author(s) -

Yang Yiqing,

Liu CuiCui,

Lei Xiaohua,

Wang Hongtao,

Su Pei,

Ru Yongxin,

Ruan Xinhua,

Duan Enkui,

Feng Sizhou,

Han Mingzhe,

Xu Yuanfu,

Shi Lihong,

Jiang Erlie,

Zhou Jiaxi

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0080

Subject(s) - thrombopoiesis , augment , microbiology and biotechnology , chemistry , computational biology , biology , stem cell , progenitor cell , philosophy , linguistics , megakaryocyte

Platelet transfusion has been widely used in patients undergoing chemotherapy or radiotherapy; however, the shortage of the platelet supply limits the care of patients. A rotary cell culture system (RCCS) was evaluated to potentiate megakaryopoiesis and significantly improve the efficiency of platelet generation. The cost‐effective and highly controllable strategy and methodology represent an important step toward large‐scale platelet production for future biomedical and clinical applications.

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