Open AccessIntegrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three‐Dimensional Rotary Culture System
Author(s) -
Yang Yiqing,
Liu CuiCui,
Lei Xiaohua,
Wang Hongtao,
Su Pei,
Ru Yongxin,
Ruan Xinhua,
Duan Enkui,
Feng Sizhou,
Han Mingzhe,
Xu Yuanfu,
Shi Lihong,
Jiang Erlie,
Zhou Jiaxi
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0080
Subject(s) - platelet , platelet transfusion , thrombopoiesis , economic shortage , medicine , computer science , immunology , haematopoiesis , biology , stem cell , microbiology and biotechnology , linguistics , philosophy , government (linguistics) , megakaryocyte
Platelet transfusion has been widely used in patients undergoing chemotherapy or radiotherapy; however, the shortage of the platelet supply limits the care of patients. A rotary cell culture system (RCCS) was evaluated to potentiate megakaryopoiesis and significantly improve the efficiency of platelet generation. The cost‐effective and highly controllable strategy and methodology represent an important step toward large‐scale platelet production for future biomedical and clinical applications.