Open AccessExtracellular Vesicles Improve Post‐Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
Author(s) -
Doeppner Thorsten R.,
Herz Josephine,
Görgens André,
Schlechter Jana,
Ludwig Anna-Kristin,
Radtke Stefan,
de Miroschedji Kyra,
Horn Peter A.,
Giebel Bernd,
Hermann Dirk M.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0078
Subject(s) - neurogenesis , mesenchymal stem cell , stem cell , extracellular vesicle , neuroregeneration , medicine , neuroprotection , progenitor cell , stroke recovery , angiogenesis , immune system , microvesicles , bone marrow , neural stem cell , stem cell therapy , regeneration (biology) , immunosuppression , immunology , pathology , neuroscience , biology , cancer research , pharmacology , microbiology and biotechnology , microrna , biochemistry , physical therapy , gene , rehabilitation
The effects of mesenchymal stem cell (MSC)‐derived extracellular vesicles were compared with those of MSCs i.v. delivered 1, 3, and 5 days or 1 day after focal cerebral ischemia in mice. Motor coordination deficits, brain injury, immune responses in peripheral blood and brain, and cerebral angiogenesis and neurogenesis were analyzed. Postischemic immunosuppression was attenuated in peripheral blood 6 days after ischemia, providing an appropriate external milieu for successful brain remodeling.