Open AccessDifferentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells
Author(s) -
Grow Douglas A.,
Simmons DeNard V.,
Gomez Jorge A.,
Wanat Matthew J.,
McCarrey John R.,
Paladini Carlos A.,
Navara Christopher S.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0073
Subject(s) - induced pluripotent stem cell , dopaminergic , pars compacta , biology , neuroscience , substantia nigra , baboon , embryonic stem cell , dopamine , stem cell , transplantation , midbrain , microbiology and biotechnology , central nervous system , medicine , endocrinology , biochemistry , gene
This study differentiated baboon fibroblast‐derived induced pluripotent stem cells into dopaminergic neurons with the application of specific morphogens and growth factors. The results show the utility of the baboon model for testing and optimizing the efficacy and safety of stem cell‐based therapeutic approaches for the treatment of Parkinson's disease.