Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells | Zendy

Grow Douglas A. | Zendy; Simmons DeNard V. | Zendy; Gomez Jorge A. | Zendy; Wanat Matthew J. | Zendy; McCarrey John R. | Zendy; Paladini Carlos A. | Zendy; Navara Christopher S. | Zendy

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Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells

Author(s) -

Grow Douglas A.,

Simmons DeNard V.,

Gomez Jorge A.,

Wanat Matthew J.,

McCarrey John R.,

Paladini Carlos A.,

Navara Christopher S.

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0073

Subject(s) - induced pluripotent stem cell , dopaminergic , pars compacta , biology , neuroscience , substantia nigra , baboon , dopamine , embryonic stem cell , stem cell , midbrain , microbiology and biotechnology , central nervous system , endocrinology , gene , biochemistry

This study differentiated baboon fibroblast‐derived induced pluripotent stem cells into dopaminergic neurons with the application of specific morphogens and growth factors. The results show the utility of the baboon model for testing and optimizing the efficacy and safety of stem cell‐based therapeutic approaches for the treatment of Parkinson's disease.

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