Open AccessSubcutaneous Transplantation of Neural Precursor Cells in Experimental Autoimmune Encephalomyelitis Reduces Chemotactic Signals in the Central Nervous System
Author(s) -
Ravanidis Stylianos,
Poulatsidou Kyriaki Nepheli,
Lagoudaki Roza,
Touloumi Olga,
Polyzoidou Elena,
Lourbopoulos Athanasios,
Nousiopoulou Evangelia,
Theotokis Paschalis,
Kesidou Evangelia,
Tsalikakis Dimitrios,
Karacostas Dimitrios,
Grigoriou Maria,
Chlichlia Katerina,
Grigoriadis Nikolaos
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0068
Subject(s) - experimental autoimmune encephalomyelitis , transplantation , multiple sclerosis , myelin oligodendrocyte glycoprotein , immunology , central nervous system , medicine , encephalomyelitis , immune system , biology , endocrinology
The effects of neural precursor cell (NPC) transplantation on the clinical course and the pathological features of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, were studied in mice. NPC recipients exhibited improved clinical outcome and less pronounced pathological features in their spinal cord. NPCs ameliorated EAE potentially by modulating the levels of chemokines expressed in the inflamed CNS, thus resulting in the impaired recruitment of immune cells.