Open AccessAdult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin‐Induced Pulmonary Fibrosis
Author(s) -
Henry Eric,
Cores Jhon,
Hensley M. Taylor,
Anthony Shirena,
Vandergriff Adam,
de Andrade James B.M.,
Allen Tyler,
Caranasos Thomas G.,
Lobo Leonard J.,
Cheng Ke
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0062
Subject(s) - lung , stem cell , progenitor cell , mesenchymal stem cell , pathology , bleomycin , pulmonary fibrosis , idiopathic pulmonary fibrosis , lung cancer , cancer research , medicine , biology , fibrosis , immunology , microbiology and biotechnology , chemotherapy
A rapid and robust method to generate therapeutic resident lung progenitors from adult lung tissues is reported. Outgrowth cells from healthy lung explants were self‐aggregated into three‐dimensional lung spheroids. Lung spheroid cells inhibited apoptosis, fibrosis, and infiltration but promoted angiogenesis and outperformed adipose‐derived mesenchymal stem cells, suggesting that lung spheroids and lung spheroid cells from healthy lung tissues are excellent sources of regenerative lung cells for therapeutic lung regeneration.