Open AccessConcise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes
Author(s) -
Schulz Thomas C.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0058
Subject(s) - endoderm , stem cell , population , embryonic stem cell , transplantation , bioprocess , diabetes mellitus , in vivo , biology , microbiology and biotechnology , medicine , endocrinology , biochemistry , paleontology , environmental health , gene
The cellular component of ViaCyte's VC‐01 combination product for type 1 diabetes matures after transplantation and functions to regulate blood glucose in rodent models. The aims in manufacturing this product at scale are to generate a consistent and robust transplantable population that functions reliably and safely in vivo.