Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes | Zendy

Schulz Thomas C. | Zendy

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Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes

Author(s) -

Schulz Thomas C.

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0058

Subject(s) - endoderm , stem cell , population , embryonic stem cell , transplantation , bioprocess , diabetes mellitus , in vivo , biology , microbiology and biotechnology , medicine , endocrinology , biochemistry , paleontology , environmental health , gene

The cellular component of ViaCyte's VC‐01 combination product for type 1 diabetes matures after transplantation and functions to regulate blood glucose in rodent models. The aims in manufacturing this product at scale are to generate a consistent and robust transplantable population that functions reliably and safely in vivo.

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