Open AccessPerivascular Mesenchymal Stem Cells From the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High Mesodermal Differentiation Potential
Author(s) -
Lojewski Xenia,
Srimasorn Sumitra,
Rauh Juliane,
Francke Silvan,
Wobus Manja,
Taylor Verdon,
Araúzo-Bravo Marcos J.,
Hallmeyer-Elgner Susanne,
Kirsch Matthias,
Schwarz Sigrid,
Schwarz Johannes,
Storch Alexander,
Hermann Andreas
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0057
Subject(s) - mesenchymal stem cell , biology , human brain , stem cell , clinical uses of mesenchymal stem cells , stem cell transplantation for articular cartilage repair , pathology , cellular differentiation , pericyte , neural stem cell , adult stem cell , microbiology and biotechnology , neuroscience , endothelial stem cell , medicine , in vitro , genetics , gene
This study characterized adult brain perivascular cells derived from human neural tissue concerning neural and mesenchymal stem cell (MSC) marker expression, transcriptomics, and mesodermal and inherent neuroectodermal differentiation potential in vitro and in vivo after in utero transplantation and showed a lack of an innate neuronal but high mesodermal differentiation potential. Because of their relationship to MSCs, these adult brain perivascular mesodermal cells are of great interest for possible autologous therapeutic use.