Perivascular Mesenchymal Stem Cells From the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High Mesodermal Differentiation Potential | Zendy

Lojewski Xenia | Zendy; Srimasorn Sumitra | Zendy; Rauh Juliane | Zendy; Francke Silvan | Zendy; Wobus Manja | Zendy; Taylor Verdon | Zendy; Araúzo-Bravo Marcos J. | Zendy; Hallmeyer-Elgner Susanne | Zendy; Kirsch Matthias | Zendy; Schwarz Sigrid | Zendy; Schwarz Johannes | Zendy; Storch Alexander | Zendy; Hermann Andreas | Zendy

Open Access

Perivascular Mesenchymal Stem Cells From the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High Mesodermal Differentiation Potential

Author(s) -

Lojewski Xenia,

Srimasorn Sumitra,

Rauh Juliane,

Francke Silvan,

Wobus Manja,

Taylor Verdon,

Araúzo-Bravo Marcos J.,

Hallmeyer-Elgner Susanne,

Kirsch Matthias,

Schwarz Sigrid,

Schwarz Johannes,

Storch Alexander,

Hermann Andreas

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0057

Subject(s) - mesenchymal stem cell , biology , stem cell , cellular differentiation , pathology , microbiology and biotechnology , medicine , genetics , gene

This study characterized adult brain perivascular cells derived from human neural tissue concerning neural and mesenchymal stem cell (MSC) marker expression, transcriptomics, and mesodermal and inherent neuroectodermal differentiation potential in vitro and in vivo after in utero transplantation and showed a lack of an innate neuronal but high mesodermal differentiation potential. Because of their relationship to MSCs, these adult brain perivascular mesodermal cells are of great interest for possible autologous therapeutic use.

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