Open AccessDrug Transporter‐Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics
Author(s) -
Boesch Maximilian,
Zeimet Alain G.,
Rumpold Holger,
Gastl Guenther,
Sopper Sieghart,
Wolf Dominik
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0054
Subject(s) - ionophore , nigericin , salinomycin , cancer stem cell , stem cell , population , biology , cancer cell , side population , abcg2 , antibiotics , cancer , pharmacology , cancer research , atp binding cassette transporter , transporter , biochemistry , medicine , microbiology and biotechnology , genetics , environmental health , membrane , gene
Testing of well‐characterized human cancer cell lines was applied to elaborate on whether drug transporters are involved in protection from the cytotoxic effects of the ionophore antibiotics salinomycin and nigericin. The results showed that ionophore antibiotics are less suited to cancer stem cell‐targeted treatment than previously thought.