Open AccessGeneration of Self‐Renewing Hepatoblasts From Human Embryonic Stem Cells by Chemical Approaches
Author(s) -
Zhang Muzi,
Sun Pingxin,
Wang Yusheng,
Chen Junnan,
Lv Linjie,
Wei Wanguo,
Jin Caixia,
Li Wenlin
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0051
Subject(s) - biology , stem cell , induced pluripotent stem cell , adult stem cell , microbiology and biotechnology , embryonic stem cell , kosr , somatic cell , induced stem cells , stem cell therapy , biochemistry , gene
Chemical approaches using small molecules to steer biological systems toward specific outcomes have been proven to be especially useful in studying stem cell biology. This study demonstrates the use of chemical approaches in maintaining human embryonic stem cell‐derived hepatoblasts in a stable, self‐renewing state. A similar strategy could be explored to enable self‐renewal of other clinically relevant somatic stem cells originally derived from human pluripotent stem cells.