Open AccessBone Morphogenetic Protein‐2 Induces Donor‐Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells
Author(s) -
Vanhatupa Sari,
Ojansivu Miina,
Autio Reija,
Juntunen Miia,
Miettinen Susanna
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0042
Subject(s) - adipogenesis , adipose tissue , bone morphogenetic protein 2 , microbiology and biotechnology , stem cell , chemistry , bone morphogenetic protein , bone morphogenetic protein 7 , biology , in vitro , biochemistry , gene
The effects of bone morphogenetic protein‐2 (BMP‐2) on SMAD1/5 signaling, proliferation, and differentiation in human adipose stem cells (hASCs) were analyzed. BMP‐2 induced dose‐dependent activation of SMAD signaling and decreased proliferation in all the cell lines studied. Furthermore, depending on the hASC donor line, BMP‐2 also induced osteogenic and adipogenic differentiation in hASCs.